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Mitophagy has a biphasic effect: moderate mitophagy helps clear damaged mitochondria and limit inflammation, but insufficient or excessive mitophagy can lead to damage accumulation or energy depletion, respectively, thereby promoting cell death (208, 209)
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Importantly, the triple-helix conformation demonstrates superior radical-quenching efficacy, with significantly elevated antioxidant activity across standardized assays: DPPH (IC 50 = 2.498 mg/mL), ABTS (IC 50 = 3.413 mg/mL), FRAP (44.73 ± 2.88 μmol Fe 2+ /g), and ORAC (47.09 ± 5.68 μmol TE/g)
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