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The remaining 5% of absorbed acetaminophen is oxidized by cytochrome enzymes, mainly CYP2E1, to produce N -acetyl-p-benzoquinoneimine (NAPQI), a highly reactive and short-lived oxidation product or electrophile (Figure 3) (1–3,51)
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Glutathione and copper, zinc superoxide dismutase are modulated by overexpression of neuronal nitric oxide synthase
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