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Science 233 , 1314–1316 (1986)

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If you're generally healthy and want the best evidence-to-cost ratio, start with a daily oral NR or NMN at studied doses, because that's where the human trials live and where sustainability is highest.[1][2] Measure your intracellular NAD+ first, retest after four to six weeks, and let your number — not a brochure — decide whether to escalate.[21] Reserve injectable NR-based formats for when you want parenteral delivery without the time cost of a drip, and reserve IV for genuine clinical indications or supervised programs, going in clear-eyed that you're paying the highest price for the thinnest evidence.[6][7] A quiet word on the meta-point, since it's the real subject underneath the molecule: the compounding returns of good health decisions are enormous, and they start now