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The MyD88-dependent arm of TLR4 signaling drives IRAK1/4-TRAF6-TAK1-mediated IKKβ activation, resulting in persistent nuclear translocation of RelA:p50 dimers and lethal immune hyperactivation [23]
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10.1124/jpet.105.088104 121 TatsumiS.MatsuokaH.HashimotoY.HattaK.MaedaK.KamoshidaS
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