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Calculations The fractional synthesis rate (FSR) of erythrocyte GSH (FSR GSH ) was calculated according to the precursor-product equation: FSR GSH (%/day) = (IR t7 − IR t5 )/(IR rbc × 1,200/t 7 − t 5 ), where IR t 7 − IR t 5 is the increase in the isotope ratio of erythrocyte GSH-bound glycine between the fifth and seventh hours of infusion, when the isotope ratio of erythrocyte-free glycine, IR rbc , had reached a steady state