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For the 5-hydroxytryptamine pathway, exploring selective 5-HT receptor antagonists or inhibiting TPH1 to reduce intratumoral 5-HT production represents a promising direction

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These discrepancies might be explained and reconciled by recent studies, which demonstrated that after amino acid deprivation, the proteasome moves from its predominant location in the nucleus to the cytoplasm, promoting protein degradation in the cytoplasm and thereby supplying the amino acids necessary for cell survival