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4E, bottom panel) revealed strong enrichment of glycine and serine metabolism, arginine and proline metabolism, the urea cycle, the Warburg effect, alanine metabolism, aspartate metabolism, glutamate metabolism, and methionine metabolism, with additional overrepresentation in pathways linked to nucleotide metabolism, gluconeogenesis, the pentose phosphate pathway, and pyruvate metabolism

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Ferroptotic cells activate macrophage functions and recruitment through damage-associated molecular patterns (DAMPs), which are endogenous danger signals that recruit and activate macrophages, thereby initiating immune defense mechanisms