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We also observed an increased level of oxidized glutathione (GSSG) in QCG supplemented RBCs after exposure to either Pf CM (1525 mean peak area intensity for 0 µM QCG vs 6725 for 1000 µM QCG, p = 0.009) ( Figure 5C ) or H 2 O 2 (111,650 mean peak area intensity for 0 µM QCG vs 211,245 for 1000 µM QCG, p = 0.103) ( Supplemental Figure 2B) compared to RBCs without QCG supplementation or exposure to oxidative stress

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Most approaches focused on enhancing the supply of energetic substrates, manipulating metabolic fluxes, or optimizing mitochondrial function 16

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