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[260] Other studies have also found large increases in resource use for low back pain despite only modest increase in its prevalence and little improvement in patient outcomes, [261 262 263] which underscores the need for more precise measure of resource use and quality of care

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The activity of specific miRNAs, such as miR-126 and miR-205, to modulate key pathways associated with tumor progression and angiogenesis highlights their significance in disease mechanisms and their potential as therapeutic targets