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Cytochrome P450 2E1 (CYP2E1), located in the endoplasmic reticulum and reliant on NADPH ( 2 O 2 ) and hydroxyl radicals (OH−) ( (3) Other Oxidative Pathways: These include reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-catalase (CAT) and xanthine oxidase-catalase (XO-CAT) systems (Zima et al., 2001)
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