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The critical distinction is DAC versus no-DAC: CJC-1295 with DAC binds albumin and circulates for roughly 6 to 8 days, whereas the no-DAC form (Mod GRF 1-29) has a half-life measured in minutes
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Structurally, it is classified as a low-molecular-weight endogenous peptide with a γ-peptide linkage between the glutamyl and cysteinyl residues, which distinguishes it from linear peptides defined by α-linkages
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