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Replying to @Shayan khan BPC 157 the crazy healerβ¦? π€π€π€ Surprisinglyβ¦yes. Or at least it seems to be based on the current available evidence. One of my sponsors, Transcend even carries it, however I ...
First, it interacts with electrophilic groups and scavenges free radicals such as hydrogen peroxide and superoxide with the help of its thiol side chain [7,9]
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Documented effects include: Upregulation of SOD1 (cytosolic Cu/Zn-SOD), CAT (catalase), and GPX1 (glutathione peroxidase 1) mRNA and protein in multiple cell types NRF2 nuclear translocation and ARE-driven gene induction (HO-1, NQO1, GCLC, TXNRD1) Reduction of 4-hydroxynonenal (4-HNE) adducts and 8-hydroxy-2β²-deoxyguanosine (8-OHdG) β markers of lipid peroxidation and oxidative DNA damage respectively Mitochondrial ROS reduction via Complex IV cuproenzyme enhancement (cytochrome c oxidase activity assay) Epitalonβs antioxidant activity is primarily documented via melatonin restoration (melatonin is itself a potent radical scavenger) and through modest upregulation of SOD and catalase in aged rodent tissues β a secondary effect rather than a primary mechanism
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