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Less commonly, more serious complications can arise, including: an abscess, or collection of pus tissue necrosis, or tissue death granuloma, or inflammation in the tissue muscle fibrosis, or scarring of muscle tissue hematoma, where blood seeps out of blood vessels into the surrounding tissue injury to blood vessels and nerves People who notice the following symptoms should call a doctor immediately: severe pain at the injection site prolonged or excessive bleeding tingling or numbness around the muscle redness, swelling, or warmth at the injection site drainage at the injection site signs of an allergic reaction, such as swelling or breathing problems Intramuscular injections are a common and effective way to deliver medication

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4 Although acne formation involves a combination of increased sebum formation, follicular hyperkeratinization, proliferation of skin bacteria, and inflammation, the main organism thought to be responsible is Propionibacterum acnes