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Pharmacological or genetic suppression of caspase activity has been shown to reduce chondrocyte apoptosis and promote expression of cartilage-specific markers such as COL2A1 and aggrecan in experimental models ( Modulation of the Bcl-2 protein family constitutes another pivotal strategy
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Two mechanisms are suspected: ASA can bind with transition elements, such as chromium [229,230], but increased absorption could also relate to competition for binding sites on ligands in intestinal absorption between chromium and other metals, like zinc and iron [260,261]
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