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Moreover, elevated GSH levels can protect tumor cells by reducing the cytotoxic effects of several chemotherapy drugs, including cisplatin, doxorubicin, melphalan, and paclitaxel, ultimately leading to drug resistance [17]
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It has been known since 1978 that B6 depletion by peripheral carbidopa depletes central dopamine by compromising the B6 enzyme AADC, 41 an event that induces PD reversible symptom deterioration and facilitates irreversible PN
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