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The p53–p21 axis has been modulated with small molecule inhibitors, antioxidants, and novel compounds to delay senescence and enhance stress resistance [157]
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3.5 Parallel defense pathways: GPX4, DHODH, and FSP1 Although the GPX4–GSH axis is widely recognized as the primary defense line against plasma membrane lipid peroxidation and ferroptosis, recent discoveries have identified GPX4-independent parallel defense mechanisms within cells, revealing the complexity and redundancy of the cellular antioxidant network
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