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Shortly afterwards, improved MDM2- p53 complex inhibitors have been developed to increase specificity and efficacy ( in vitro on PPARγ agonist exposure ( Overall, most of the DDLPS targeted treatment trials have shown poor clinical efficacy when compared with the objective response rate estimated to be 26% for DDLPS first-line anthracycline-based chemotherapy ( 4.4.3 Radiotherapy Regarding the efficacy of radiotherapy, most researchers believe that local radiotherapy is more efficient for uninfiltrated tumors ( However, there is no clear evidence that localized radiotherapy is beneficial for DDLPS