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Lastly, thorough preclinical and clinical head-to-head studies are needed to carefully explore different types of ferroptosis regulators and determine their therapeutic windows for various cancer types over longer experimental periods, in order to assess efficacy, drug compatibility, drug resistance, and related side effects
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SGLT-2Is block renal glucose reabsorption to promote urinary excretion, while GLP-1RAs enhance glucose-dependent insulin secretion and suppress glucagon release (Prattichizzo et al., 2021)
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