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SOD1 was the first identified ALS-associated gene, and mutations alter the protein conformation to expose hydrophobic surfaces and facilitate the aggregation (Wang L

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It has been established that the oxidizing enzymes, polyphenoloxidases, peroxidases, and ascorbinoxidases are inhibited in the case of using large doses of sulfur dioxide, acting on the prosthetic groups found in the enzymes [138]