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Cells deficient in GPx1 generated more ROS, in the presence and absence of TNFα, as measured intracellularly by DCF fluorescence or extracellularly, as measured by Amplex Red detection of hydrogen peroxide in the media [6]
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However, it is unknown to what extent acetaminophen-induced neuropathology can be induced by the recommended dose of the drug, and to what extent excessive doses are responsible for the induction of neurological disorders in the pediatric population
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